This is a single center pilot study testing the use of novel coil arrays with MR liver imaging. In part A of the study, up to 30 healthy volunteers will be scanned, with iterative adjustment of coil array geometry and design to optimize imaging characterstics. In Part B of the study, 40 patients with advanced solid tumors and at least one liver metastasis measuring \> 1.5 cm in diameter on standard anatomic scans will undergo MR liver imaging with the newly designed coil array, with the use of gadolinium contrast. Patients with liver tumors will have the option of undergoing a second MR liver scan during the course of subsequent systemic therapy.
Study Type
OBSERVATIONAL
Enrollment
7
University of California, San Francisco
San Francisco, California, United States
Spatial Resolution
Adjust the coil array to optimize spatial resolution in healthy volunteers
Time frame: Day 1
Scan coverage
Adjust the coil array to optimize scan coverage of the liver in healthy volunteers
Time frame: Day 1
Mean contrast-to-noise ratio
Detectable using the coil array
Time frame: Day 1
Minimum size of detectable metastatic lesion
Detected by MRI scan
Time frame: Day 1
Degree signal
Detected by gandolinium contrast in MRI scan within liver metastases
Time frame: Day 1
Time-to-peak signal
Detected by gandolinium contrast in MRI scan within liver metastases
Time frame: Day 1
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