Vaccination in Prostate Cancer (VANCE)

Inclusion Criteria(Radical Prostatectomy patients): * Males aged 18 years and older * Histologically confirmed prostate cancer diagnosed on biopsy within 6 months * Clinically localised, low or intermediate risk prostate cancer, i.e.: * Gleason score ≤ 7 * Local tumour stage ≤T2c * No evidence of metastases (Nx/N0 and Mx/M0) * PSA ≤ 20 ng/ml * Scheduled for and considered fit for radical prostatectomy * Absence of any indication to perform urgent surgery that would not allow administration of the vaccine during the 12 week period prior to radical prostatectomy * No invasive treatment for prostatic disease within the last 2 years * Subject is free of clinically apparent/active autoimmune disease (no prior confirmed diagnosis or treatment for autoimmune disease including Systemic Lupus Erythematosis, Grave's Disease, Hashimoto's Thyroiditis, Multiple Sclerosis, and Insulin Dependent Diabetes Mellitus). Note subjects with Non-Insulin Dependent Diabetes Mellitus can be included. * Subject has adequate bone marrow function as defined by an Absolute Lymphocyte Count (ALC) ≥ 500/µL, Absolute Neutrophil Count (ANC) \>1200/µL, Platelet Count \>100,000/µL. * Subject must practice a reliable form of contraception (barrier or vasectomy) while they are being treated with vaccines and another effective method of birth control must also be used by their partner Inclusion Criteria (Active Surveillance patients) * Males aged 18 and older * Histologically confirmed prostate cancer diagnosed on biopsy within 6 months * Clinically localised, low or intermediate risk prostate cancer, i.e.: * Gleason score ≤ 7 * Local tumour stage ≤T2c * No evidence of metastases (Nx/N0 and Mx/M0) * PSA ≤ 20 ng/ml * Stable disease on Active Surveillance for a minimum of 12 months previously * Suitable to remain on Active Surveillance at time of last clinical assessment * No invasive treatment for prostatic disease within the last 2 years * Subject is free of clinically apparent/active autoimmune disease (no prior confirmed diagnosis or treatment for autoimmune disease including Systemic Lupus Erythematosis, Grave's Disease, Hashimoto's Thyroiditis, Multiple Sclerosis, and Insulin Dependent Diabetes Mellitus). Note subjects with Non-Insulin Dependent Diabetes Mellitus can be included. * Subject has adequate bone marrow function as defined by an Absolute Lymphocyte Count (ALC) ≥ 500/µL, Absolute Neutrophil Count (ANC) \>1200/µL, Platelet Count \>100,000/µL. * Subject must practice a reliable form of contraception (barrier or vasectomy) while they are being treated with vaccines and another effective method of birth control must also be used by their partner Exclusion Criteria: * Diagnosis of any cancer other than prostate cancer within the last 5 years (except basal cell carcinoma) * Any suspicion of metastatic cancer * Any Gleason grade 5 component in the prostatic biopsies * Participation in another research study involving an investigational product in the 30 days preceding enrolment, or planned use during the study period * Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate * Seropositive for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) or HIV * Any confirmed or suspected immunosuppressive or immunodeficient state, asplenia, recurrent, severe infections and chronic (more than 14 days) immunosuppressant medication within the past 6 months (inhaled/topical steroids are allowed) * Platelet count \>400,000/μL; Monocytes \>80,000/μL; Hemoglobin \<11g/dL * Known allergy to neomycin * History of allergic response to previous vaccinia vaccinations * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine, e.g. egg products * History of hypersensitivity and haemorrhagic cystitis * Any history of anaphylaxis * Suspected or known current injecting drug or alcohol abuse (as defined by an alcohol intake of greater than 42 units per week) * History of a serious psychiatric condition or other circumstance s that may be associated with not understanding or complying with the study protocol