Stable Asthma patients (GINA 1-2) stay 6 days in a row for 4 hours per day in a hypoxic chamber simulating 2800m above sea level. Study participants will be blinded to the treatment given and divided into a hypoxic and a sham group (about 360m above sea level). Effects of this intermittent hypoxia on the asthmatic inflammation of these patients will be measured. The primary endpoint is the change in forced exhaled nitric oxide (FeNO) before and after the study. Secondary endpoints include blood parameters, lung function testing and questionnaires.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
21
Intervention lasts 4 hours per day for 6 days in a row.
Intervention lasts 4 hours per day for 6 days in a row.
Pulse oximetry will be performed hourly during sessions in the hypoxic chamber for safety reasons.
Medical University of Graz
Graz, Styria, Austria
Change in forced exhaled nitric oxide after 6 days of hypoxia/sham
Forced exhaled nitric oxide will be measured every day before and after the treatment
Time frame: 1 week
Change in blood parameters after 6 days of hypoxia/sham
Blood parameters including c-reactive protein, complete blood cell count, total immunoglobulin e (IgE), specific IgE of seasonal inhalative antigens and eosinophilic cationic protein will be measured. Blood samples will be taken before the first and after the last intervention
Time frame: 1 week
Change in lung function parameters after 6 days of hypoxia/sham
Lung function testing will be performed before the first and after the last intervention
Time frame: 1 week
Change in Quality of Life and Asthma questionnaires after 6 days of hypoxia/sham
Questionnaires include Asthma Control Test, Asthma Quality of Life Questionnaire, Asthma Control Questionnaire, a quality of life questionnaire and the Asthma Control Diary. Documents will be collected every day before the intervention
Time frame: 1 week
Change in finger pulse oximetry
Finger pulse oximetry will be measured hourly during the intervention for safety reasons.
Time frame: 1 week
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Before every session in the hypoxic chamber as well as on the day after the last session will be completed.
On the day of the first session in the hypoxic chamber as well as on the day after the last session lung function testing will be performed.
On the day of the first session in the hypoxic chamber as well as on the day after the last session blood samples will be taken.
Before every session in the hypoxic chamber as well as on the day after the last session FeNO (forced exhaled nitric oxide) measurement will be performed.