The aim of this study is to investigate the effect of daily intake of the probiotic Lactobacillus Reuteri on the prevalence and counts of oral Candida in frail elderly living in nursery homes.
The aim of the present study was to investigate the effect of a twice daily intake of lozenges containing probiotic Lactobacillus reuteri on the prevalence and counts of oral Candida in senior residents living in nursery homes. The material consists of 215 elderly persons (range 60 to 102 years) living in 20 different nursery homes in the County of Kronoberg, situated in the southern parts of Sweden. The subjects were consecutively enrolled after informed consent consisting of verbal and written information directed to the individual as well as to their relatives. The study employed a double-blind randomized placebo-controlled design.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
215
Ingestion of active lozenge twice daily for 12 weeks
Ingestion of placebo lozenge twice daily for 12 weeks
Prevalence of oral Candida growth assessed from chair-side tests.
Saliva and plaque samples will be analyzed and data presented when all 215 participants have completed the intervention period.
Time frame: Baseline and 12 weeks.
Amount of oral Candida growth assessed from chair-side tests.
Saliva and plaque samples will be analyzed and data presented when all 215 participants have completed the intervention period.
Time frame: Baseline and 12 weeks.
Change in levels of dental plaque
Secondary Outcome Measures will be measured before and after the intervention period.
Time frame: Baseline and 12 weeks.
Changes in levels of gingival bleeding.
Secondary Outcome Measures will be measured before and after the intervention period.
Time frame: Baseline and 12 weeks.
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