Clinical Evaluation of Noninvasive OCT Angiography Using a Zeiss OCT Prototype to Compare to Fluorescein Angiography

Association for Innovation and Biomedical Research on Light and Image62 enrolled

Overview

Clinical evaluation of noninvasive OCT Angiography using a Zeiss OCT Prototype to replace fluorescein angiography.

Fluorescein angiography (FA) is the standard and generally accepted method to identify vascular features in the retina, detecting capillary dropout and neovessel growth. Its value is undeniable and is a routine ophthalmological examination. However, it requires intravenous injection of fluorescein, which can cause nausea, vomiting and, rarely, anaphylaxis and death. New OCT angiography methods can detect, noninvasively red blood cells flow and, therefore, identify well the retinal vasculature. It is crucial and of major interest to evaluate the clinical utility of this new methodology comparing this information with the one obtained from fluorescein angiography.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetic Retinopathy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with clinical indication for fluorescein angiography in their clinical practice Exclusion Criteria: * Subjects with a pacemaker of similarly critical electronic device * Subjects with severe ocular media opacities * Subjects with corneal abnormalities

Locations (1)

Aibili - Cec

Coimbra, Portugal

Outcomes

Primary Outcomes

Comparison between examination techniques on the detection of morphological changes in the retina (such as vessels morphology, vascular ischemia, retinal neovascularization, choroidal neovascularization, and other vascular abnormalities).

Time frame: Single Visit

Data from ClinicalTrials.gov

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