The Hasselt APPendicitis Immunology and Environmental Cohort STudy

Hasselt University308 enrolled

Overview

The Hasselt Appendicitis Immunology and Environmental Study (HAPPIEST) aims at characterizing factors that influence the development and severity of acute appendicitis. In a cohort of 300 patients and 300 controls, environmental factors as well as genetic make-up of the innate immune system, focusing mainly on pattern recognition, will be analyzed in order to gain insight in their relative importance in the pathology of appendicitis. Furthermore, populations of micro-organisms present in the gut of patients will be characterized, and the interaction between relevant micro-organisms and the innate immune system will be analyzed.

Study Type

OBSERVATIONAL

Enrollment

308

Conditions

Appendicitis

Eligibility

Sex: ALLMin age: 5 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Acute appendicitis * Appendectomy within 7 days after onset of symptoms * Signed informed consent Exclusion Criteria: * Appendectomy 7 days or more after onset of symptoms * Participation in any clinical investigational drug study within 4 weeks of screening * Severe, life-threatening disease with a life expectancy of less than 2 months.

Locations (2)

Jessa Ziekenhuis

Hasselt, Limburg, Belgium

Radboud University Medical Center

Nijmegen, Gelderland, Netherlands

Outcomes

Primary Outcomes

Genetic susceptibility

DNA sample collected at inclusion

Time frame: Within 2 years after inclusion of the last patient

Secondary Outcomes

Immunology composite outcome

ex vivo peripheral blood mononuclear cell (PBMC) stimulation experiments

Time frame: within 4 years

Environmental factors

Questionnaire filled in at inclusion

Time frame: Within 6 months after inclusion of the last patient

Data from ClinicalTrials.gov

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