Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets

Inclusion Criteria: * Men or women, aged between 25 and 60 years * Patients with at least 20 natural teeth * Patient with periodontitis confirmed by a X-ray diagnosis, and having at least 4 teeth with periodontal pockets with probing depth between 4 and 6 mm * Willing to understand and comply with study requirements and to sign informed consent Exclusion Criteria: * Patient with an active smoking status * Patient with an antibiotic therapy within the previous 4 weeks * Need for continuous medical treatment within 2 weeks prior to enrollment * Ongoing inflammatory state or a systemic illness that may affect the oral cavity * Patient with hypofunction in saliva productions (e.g. Sjögren Syndrome with Xerostomia) * History of active chronic debiliating systemic disease, including insulin or non-insulin dependent diabetes * Patients with bleeding disorders * History of allergies to gram positive bacterial proteins * History of hypersensitivity and/or idiosyncrasies to any of the test compounds, e.g. hyaluronic acid or other device compounds * History of multiple severe allergies, history of anaphylactic shock * History of connective tissue disease (rheumatoid arthritis, scleroderma, systemic lupus erythematosus) or of any other autoimmunity disease * History of herpetic lesion or lichen planus * Pregnant or breast feeding women, or female subjects of childbearing potential who did not intend to practice medically acceptable method of contraception * Participation in another clinical study in the previous 3 months