Variable Interval Versus Set Interval Aflibercept for DME

Inclusion Criteria: 1. Adults 18 years and older with Type 1 or Type 2 diabetes mellitus 2. Patients with diabetic macular edema involving the center of the macular in the study eye (CST must measure at least 350µm on Heidelberg SDOCT, or 333µm on Cirrus SDOCT) 3. Decrease in vision determined to be primarily due to DME in the study eye 4. BCVA ETDRS letter score 78 to 24 (20/32 to 20/320) in the study eye 5. Willing and able to comply with clinical visits and study related procedures 6. Willing and able to provide signed informed consent Exclusion Criteria: 1. History of vitreoretinal surgery in the study eye 2. Laser photocoagulation (panretinal or macular) in the study eye within 90 days of baseline 3. Previous use of intraocular or periocular corticosteroids in the study eye within 90 days of baseline 4. History of intravitreal anti-VEGF treatments in the study within 90days prior to baseline (not including prior intravitreal aflibercept injection \[see exclusion criteria #5\]) 5. Any history of intravitreal aflibercept 6. Active proliferative diabetic retinopathy (PDR) in the study eye 7. History of idiopathic or autoimmune uveitis in the study eye 8. Cataract surgery in the study eye within 90 days of baseline 9. Aphakia in the study eye 10. Yttrium aluminum garnet (YAG) capsulotomy in the study eye within 30 days of baseline 11. Any intraocular surgery in the study eye within 90 days of day 1 12. Vitreomacular traction or epiretinal membrane in the study eye that is thought to affect central vision 13. Current iris neovascularization, vitreous hemorrhage, or traction retinal detachment in the study eye 14. Pre-retinal fibrosis involving the macula in the study eye 15. Uncontrolled glaucoma (defined as any patient who has had filtration surgery in the past, or likely to need filtration surgery in the future, or has IOP ≥30mmHg) 16. Myopia of a spherical equivalent prior to any possible refractive or cataract surgery of ≥-8 diopters 17. Concurrent disease in the study eye, other than DME, that could compromise BCVA, require medical or surgical intervention during the study period, or could confound interpretation of the results (including retinal vascular occlusion, retinal detachment, macular hole, or choroidal neovascularization of any cause) 18. Ocular media of insufficient quality to obtain fundus and SDOCT images 19. Current treatment for a systemic infection 20. Administration of systemic anti-angiogenic agents within 180 days of baseline 21. Uncontrolled diabetes mellitus, in the opinion of the investigator 22. Uncontrolled blood pressure (define as systolic \>180mmHg, or diastolic \>110mmHg while patient is sitting) 23. History of CVA or MI within 180 days of baseline 24. Renal failure requiring dialysis or renal transplant 25. Known serious allergy to fluorescein 26. Participation in an investigational study within 30 days prior to baseline that involved treatment with any drug (excluding vitamins and minerals) or device 27. Any women who are pregnant, breast-feeding, or attempting to become pregnant 28. Sexually active men\* or women of childbearing potential\*\* who are unwilling to practice adequate contraception during the study (adequate contraceptive measures include stable use of oral contraceptives or other prescription pharmaceutical contraceptives for 2 or more menstrual cycles prior to screening; intrauterine device \[IUD\]; bilateral tubal ligation; vasectomy; condom plus contraceptive sponge, foam, or jelly, or diaphragm plus contraceptive sponge, foam, or jelly) \*Contraception is not required for men with documented vasectomy. \*\*Postmenopausal women must be amenorrheic for at least 12 months in order not to be considered of child bearing potential. Pregnancy testing and contraception are not required for women with documented hysterectomy or tubal ligation.