A Hepatitis B With Hepatic Steatosis Study

Inclusion Criteria: 1. Clinically diagnosed chronic hepatitis B. 2. Specific biopsy requirements for hepatic steatosis: qualified biopsy specimen within 6 months, \>5% hepatocytes show macrovesicular steatosis under HE staining and X10 microscope. 3. Willing to participate in the long-term follow-up and cooperative. 4. Able to provide informed consent file. Exclusion Criteria: 1. Unable to provide informed consent. 2. Patients are eligible for baseline analysis but not eligible for follow-up, if having any of the following condition: 1. Any end-stage liver disease. 2. Any malignant tumor. 3. Any congenital liver disease such as Wilson disease. 4. Any other serious disease of projected survival \< 5 years.