Severe Influenza Cohort

Hospices Civils de Lyon227 enrolled

Overview

Influenza is a major cause of morbidity and mortality. The investigators first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

227

Conditions

Influenza Severe Respiratory Infection

Interventions

influenza cohortOTHER

Influenza is a major cause of morbidity and mortality. The investigators' first goal is to evaluate soluble HLA-G5 isoform serum level as a potential marker of greater risk of death from Influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. Secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.

Eligibility

Sex: ALLMin age: 1 MonthMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient (Adult or Pediatric) * Hospitalized in reanimation * With a laboratory confirmed Influenza * That agree to take part in the study * Affiliated to National Health Insurance For ancillary group : * Adult at least 60 years old * Presenting at hospital for a blood test Exclusion Criteria: * non willing to participate * Influenza infection with no respiratory symptoms * pregnancy For ancillary group : * Presence of immunodepression defined by: * Cancer, or cancer cured for less than 2 years * Corticosteroids, Methotrexate (MTX), anti Tumor Necrosis Factor (TNF), anti-CD20 * Infection in progress (fever)

Locations (15)

Centre de Biologie et de Pathologie Nord

Lyon, Auvergne-Rhône-Alpes, France

Hôpital Femme Mère Enfant

Bron, France

CHU service réanimation adulte

Clermont-Ferrand, France

Outcomes

Primary Outcomes

Change in ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2), from admission at 7 days post-admission

decreased arterial PaO2/FiO2 ratio ≤ 100 mmHg (≤ 13.3 kPa)

Time frame: The first, third, fifth and seventh day of hospitalization in reanimation

Secondary Outcomes

All cause mortality

Time frame: 90 days after hospitalization

Extracorporeal membrane oxygenation requirement

Time frame: 90 days after hospitalization

SOFA score (Adult) PELOD (Pediatric)

Elevated Score is considered as an evidence of clinical gravity

Time frame: The first, third, fifth and seventh day of hospitalization in reanimation

Data from ClinicalTrials.gov

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