The purpose of this study is to determine the safety of administering obinutuzumab as a single agent alone and in combination with ifosfamide, carboplatin, and etoposide (ICE) chemotherapy and determine the response rate of this treatment for children, adolescents and young adults (CAYA) with relapsed CD20 positive B-cell Non-Hodgkin Lymphoma (B-NHL).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
25
Drug will be given alone in a pre-phase and in combination with ICE chemotherapy.
Will be given intrathecally for both prophylaxis and treatment of CNS disease.
Ifosfamide 3000 mg/m2/day as a 2 hour IV infusion daily x 3 days (Days 0,1,2) of Cycle 1 and 2.
Carboplatin: 635 mg/m2 as 1 hour IV infusion on Day 0 only of Cycle 1 and 2.
Etoposide: 100 mg/m2/day as 1 hour IV infusion daily x 3 days (Days 0,1,2).
New York Medical College
Valhalla, New York, United States
RECRUITINGSafety as assessed by adverse reactions and events
Patients will be monitored for adverse reactions and events of drug when given alone and in combination with ICE chemotherapy.
Time frame: 1 month
Response rate assessed following each treatment cycle for regression of tumor
Patients will be assessed following each treatment cycle for regression of tumor.
Time frame: 3 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.