Major surgery results in a stress- induced catabolic response, marked by post-operative insulin resistance, hyperglycemia and loss of body protein, which is associated with increased morbidity, mortality and adverse outcomes. There has been a great deal of research on different approaches to optimize post-operative insulin sensitivity including hormonal and nutritional interventions, minimally invasive surgical techniques and epidural anesthesia. However, the correlation between insulin resistance and body protein loss is not well understood. Metformin is the most widely used insulin sensitizing and blood glucose-lowering drug in treatment of type 2 diabetic patients. This study will: 1) estimate the correlation between insulin resistance and body protein loss in pre-diabetic lung/colorectal resection patients; 2) investigate whether the post-operative metabolic state can be improved by the pre-operative administration of metformin; and assess the impact of metformin on surgical complications and hospital length of stay. The results of this study will provide insight into the relationship between insulin resistance and post-operative adverse events and potentially suggest a novel approach to improve outcomes using Metformin, a drug already in wide clinical use.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
7
Montreal General Hospital
Montreal, Quebec, Canada
Change in fasting blood glucose
the level of plasma glucose after 6 hours of fasting
Time frame: 2 weeks before surgery (pre-operative) and on the morning before the surgery and every morning after the surgery (post operative) for three days or until discharge which ever comes earlier
Change in whole body protein balance
The difference between the Pre-operative whole body protein balance( prior to metformin treatment) and the post operative whole body protein balance
Time frame: 2 weeks before surgery (pre-operative) and hours after the surgery (post operative)
Comparing the Homeostasis model assessment (HOMA) index at three different time points ( by employing Fasting blood sugar and Plasma Insulin)
Time frame: at 3 time points as follow : 2 weeks before surgery, on the day of surgery and 48 hours after the surgery
glycosylated Hba1c
plasma level of glycosylated Hba1c
Time frame: 2 weeks before surgery
Comparing the pre-operative body impedance and the post operative body impedance (to asses the body composition specifically the amount of body fat)
Measures body composition specifically fat content
Time frame: 2 weeks before surgery and 48 hours after the surgery
Surgical Complications
Any complication related to the surgery with in 30 days post operation
Time frame: 30 days after operation
length of hospital stay
Length of hospital stay is calculated as the total length of hospitalization from the date of admission for the purpose of surgery until the date of discharge from the hospital
Time frame: Up to 30 days after operation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.