Perioperative Cardiac Troponin Levels in Healthy Adults

Medical University of Vienna120 enrolled

Overview

This study will determine the extent of high-sensitivity cardiac troponin (hs-cTn) release in patients without cardiac risk factors undergoing extremity orthopedic surgery. This study will provide important evidence on how to interpret postoperative cardiac troponin elevations.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Extremity Orthopedic Surgery

Interventions

Extremity orthopedic or trauma surgeryPROCEDURE

hip, leg, shoulder, arm

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-35 years * Extremity orthopedic or trauma surgery: leg, hip, arm, shoulder. * Planned overnight hospital admission * No cardiac risk factors (Lee's Revised Cardiac Risk Index Class 1) * American Society of Anesthesiologists (ASA) physical status I-II Exclusion Criteria: * Any history or symptoms of cardiac disease * Kidney or liver disease * Recent or current trauma to the trunk or head * Persons with increased vulnerability (e.g. cognitive limitations, prisoners,…) * Pregnancy

Locations (1)

Division of General Anaesthesia and Intensive Care Medicine, Medical University of Vienna

Vienna, Austria

Outcomes

Primary Outcomes

Perioperative change of high-sensitivity cardiac troponin plasma level

3 samples: 1. Preoperative, 2. POD 0, and 3. POD 1

Time frame: 24 hours preoperatively to postoperative day (POD) 1

Secondary Outcomes

Peak high-sensitivity cardiac troponin plasma level

3 samples: 1. Preoperative, 2. POD 0, and 3. POD 1

Time frame: 24 hours preoperatively to POD 1

Incidence rate of high-sensitivity cardiac troponin plasma level elevation

3 samples: 1. Preoperative, 2. POD 0, and 3. POD 1

Time frame: 24 hours preoperatively to POD 1

Data from ClinicalTrials.gov

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