Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients

Moscow Regional Research and Clinical Institute (MONIKI)

Overview

Assessment of sedative effects of sevoflurane, dexmedetomidine and propofol on the clinical course of delirium, SIRS and neuroinflammation in mechanically ventilated patients using CAM-ICU scale, GSK-3beta and protein S100b in serum.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Delirium

Interventions

SevofluraneDRUG

Treatment of delirium by inhaled sevoflurane

PropofolDRUG

Treatment of delirium by propofol i.v. infusion

DexmedetomidineDRUG

Treatment of delirium by dexmedetomidine i.v. infusion

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * presence of delirium Exclusion Criteria: * presence of Alzheimer's disease * any mental disorder * presence of cancer

Outcomes

Primary Outcomes

Duration of Delirium

Delirium assessment by CAM-ICU scale

Time frame: up to 5 days

Secondary Outcomes

Change of protein S100b in serum

Time frame: from delirium onset up to 5 days

Change of GSK-3beta in serum

Time frame: from delirium onset up to 5 days

Data from ClinicalTrials.gov

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