Healing of Persistent Epithelial Defects

Milton S. Hershey Medical Center

Overview

The purpose of this study is to compare the relative efficacy of four different treatment modalities (i.e. aggressive lubrication, bandage contact lens, Ambiodisk amniotic membrane, Prokera amniotic membrane) in the healing of persistent corneal epithelial defects following retina surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Cornea

Interventions

carboxymethylcellulose sodiumDRUG

frequent topical lubrication with artificial tears

Acuvue Oasys Bandage Contact LensDEVICE

AmbiodiskDEVICE

Prokera

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

3.1 Inclusion Criteria * Adults aged 18 and older (inclusive) at the time of study enrollment * Recent history of retina surgery * Presence of persistent epithelial defect 7 days or later after surgery * English speaking 3.2 Exclusion Criteria * Non-English speaking patients * Inability to incapacity to provide consent for the study * History of corneal epithelial or limbal stem cell disease

Locations (1)

Penn State Hershey Eye Center

Hershey, Pennsylvania, United States

Outcomes

Primary Outcomes

Abscence of persistent epithelial defect

Time frame: 22 days

Secondary Outcomes

Rate of epithelial healing in mm2/day

Time frame: 22 days

Infection

Time frame: 22 days

Data from ClinicalTrials.gov

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