Prostate Artery Embolization as a Treatment for Benign Prostatic Hyperplasia in Men With Prostates Larger Than 90 Grams

Inclusion Criteria: * Patient has provided signed informed consent * Patient is aged greater than or equal to 40 and less than or equal to 89 years of age * Patient has a prostate size between 90g and 200g, as determined by MRI * Patient has experienced lower urinary tract symptoms (LUTS) for at least 6 months prior to study enrollment * Patient has an IPSS score of at least 13 at baseline * Patient is either: refractory to medical treatment, contraindicated to medical treatment, OR refuses medical treatment * Patient either: refuses surgical treatment OR is contraindicated for surgical treatment * Patient meets ONE of the following criteria: baseline PSA \< 4.0ng/mL (no prostate biopsy required) OR baseline PSA \>/= 4 ng/mL AND a negative prostate biopsy (minimum 12 core biopsy) within the prior 12 months Exclusion Criteria: * History of prostate, bladder, or rectal cancer * History of transurethral resection of the prostate (TURP), open prostate surgery, or radiofrequency or microwave therapies * History of open bladder, rectosigmoid colon, or other pelvic surgery * Patient is unwilling to discontinue alpha blockers 1 month after study treatment * Patient is unwilling to discontinue 5-alph reductase inhibitors 1 month after study treatment * Neurogenic bladder or other neurologic disorder impacting bladder function such as Parkinson's disease, multiple sclerosis, cerebral vascular accident or diabetes * Any other confounding bladder or urethral pathology, including urethral stricture, bladder neck contracture, or bladder atonia * Active prostatitis or urinary tract infection * Cystolithiasis within the past 3 months * Serum creatinine \> 1.7mg/dL * Inability to discontinue oral anticoagulant 2-5 days prior to study treatment * Coagulation disturbances not normalized by medical treatment * Iodinated contrast allergy that, in the opinion of the Investigator, cannot be adequately premedicated * Gelatin allergy * Known severe peripheral vascular disease or major iliac arterial occlusive disease * Interest in future fertility * Clinically significant cardiac arrhythmia or other cardiac disease (including congestive heart failure), uncontrolled diabetes mellitus, clinically significant respiratory disease, or known immunosuppression * Other condition that the Investigator believes puts the patient at risk for a complication during the procedure