Three Small Doses of HCG Versus Booster Dose of HCG on Ovum Pickup Day

Cairo University200 enrolled

Overview

To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared supplementing the luteal phase with three small doses (500 IU) of HCG and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Infertility

Interventions

IVF/ICSIPROCEDURE

Human Chorionic GonadotropinDRUG

Given in different doses and timing to support the luteal phase

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 37 Years

Medical Language ↔ Plain English

Inclusion Criteria: * High responder females undergoing antagonist protocol IVF/ICSI cycle * More than 14 MII oocytes * Estradiol more than 3500 pg/ml on day of trigger Exclusion Criteria: * Any other protocol * Normal or poor responders

Locations (3)

IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini)

Cairo, Egypt

Adam International hospital

Giza, Egypt

Nile IVF center

Giza, Egypt

Outcomes

Primary Outcomes

Clinical pregnancy rate

The number of cycles with a positive pregnancy test and evidence of a gestational sac with fetal pulsations after 5weeks from pregnancy test

Time frame: 1 year

Secondary Outcomes

OHSS rate

The number of cycles with evidence of OHSS

Time frame: 1 year

Data from ClinicalTrials.gov

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