Effects of Position and a Test Meal on Esophago-gastric Junction Morphology and Function Assessed by High-resolution Impedance Manometry (HRM)

University of Zurich380 enrolled

Overview

Retrospective analysis for HRM measurements using liquid swallows and a test meal for the presence of hiatal hernia. The investigators will correlate hernia descriptions with presence of acidic reflux and clinical complaints.

We will retrospectively analyze all patients referred to hour unit for high-resolution esophageal manometry. These patients have been tested using liquid swallows and a test meal. We will analyze the HRM measurements for presence of manometric signs of hiatal hernia and determine predictive factors for hernia presence. We will correlate hernia description versus presence of acid reflux, clinical complaints and HRM measurements.

Study Type

OBSERVATIONAL

Enrollment

380

Conditions

Hiatus Hernia

Interventions

high resolution esophageal manometryOTHER

high resolution esophageal manometry using liquid and solid swallows and a test meal.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients referred to our functional lab for esophageal high-resolution manometry from January 2013 - December 20165 * Lack of documentation of patient preferences against usage of medical data for biomedical research * Male and female patients ≥18 years of age Exclusion Criteria: * Age under 18 years * Patient's wishes against scientific use of their clinical data

Locations (1)

Division of Gastroenterology, University Hospital Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Effects of hernia type (consistent hernia, transient hernia and no hernia, as specified bellow) on reflux symptoms

Time frame: 1 months

Secondary Outcomes

Differences in hernia size between sitting and recumbent position as well as between liquid swallows, free drinking and test meal.

Time frame: 1 hour

Diagnostic accuracy for hernia diagnosis by HRM for sitting, and recumbent position, free drinking and test meal.

Time frame: 1 hour

Correlation of pH-impedance measurements (if available) with manometric and clinical data.

Time frame: 1 hour

Correlation of various measurements describing esophageal motility according to Chicago classification with type of hernia, clinical symptoms and pH-impedance measurements

Time frame: 1 hour

Correlation of hernia diagnosis and hernia size according to imaging exams (if available: CT scan, fluoroscopy) and endoscopy (if available) with hernia diagnosis by HRM

Time frame: 1 hour

Correlation of body measurements (body mass index, BMI, waist circumference) of patients with type of hernia, clinical symptoms and pH-impedance measurements

Time frame: 1 hour

Correlation of visceral sensitivity (determined by balloon inflation) with reflux symptoms

Time frame: 1 hour

Prediction of reflux symptoms using a model including hernia and esophageal peristalsis characteristics, visceral sensitivity (balloon inflation) and anthropometric measurements

Data from ClinicalTrials.gov

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