Reading Disability in Children With NF1

University Hospital, Toulouse181 enrolled

Overview

A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.

To determine the phonological and visio -spatial performances at the NF1 children.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

181

Conditions

Neurofibromatosis Type 1

Interventions

Neuropsychological assessmentsOTHER

Neuropsychological assessments: Intelligence Quotient (WISC-IV) Reading tests (reading accuracy, reading speed, reading comprehension and strategy): Alouette test, Lobrot test, Odedys test. Visio-spatial skill (JLO, Thurston, Corsi tests) Attention (CPT 2, CBCL) Receptive oral language (EVIP)

Eligibility

Sex: ALLMin age: 8 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age included between 8 and 12 years * Child presenting a type 1 neurofibromatosis according to 2 criteria in the following criteria list : * At least 6 café au lait spots * 2 or more neurofibromas or 1 plexiform neurofibroma * axillary or inguinal freckling * 1 optic nerf glioma * 2 or more Lisch nodules * 1 osseous lesion as sphenoid dysplasia or thinning of the long bone cortex with or without pseudoarthrosis * 1 A first degree relative (parent, sibling, or offspring) with NF1 by the above criteria * Membership in a national insurance * Consent of the child and the parents Exclusion Criteria: * Mental retardation (QI T \< 70) * Treated or untreated epilepsy * Visual deficit (visual Acuteness \< 4/10 * Presence of a symptomatic optic glioma * Presence of a brain tumor.

Locations (6)

Hopital femme-mére-enfant, Hospices civils de lyon

Lyon, France

Hôpital Gui de Chauliac

Montpellier, France

CHU Hôtel-Dieu, Clinic of Dermatology

Nantes, France

AP-HP Hopital Armand Trousseau

Paris, France

Outcomes

Primary Outcomes

Phonological deficits evaluated by the metaphonological capabilities including a subtraction test and phonemic Acronym test and memory capacity with phonological phonological memory test.

Evaluate whether there is a specificity of phonological deficits in children with NF1 compared with a population of children with the same age and same reading level, taking into account the intellectual level.

Time frame: 24 hours

Secondary Outcomes

Visual-perceptual performance established from three tests: Test of Identical Forms (Thurstone), Judgment Test of orientation Lines (Benton) and global and partial deferral Tasks (S Valdois).

Studying the correlations between phonological deficits and visio-spatial and literacy skills.

Time frame: 24 hours

Data from ClinicalTrials.gov

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