Brentuximab for Newly Diagnosed Hodgkin Disease

Inclusion Criteria: * Normal Serum creatinine based on age or creatinine clearance \>60 ml/min/1.73 m2 or an equivalent radioisotope glomerular filtration rate (GFR) as determined by the institutional normal range. * Direct bilirubin \< 1.5 upper limit of normal (ULN) for age, and SGOT (AST) or SGPT (ALT) \<3 x ULN * Shortening fraction \>27% by echocardiogram, or * Ejection fraction of \>50% by radionuclide angiogram or echocardiogram. * For patients age 1-16 years, Lansky score of ≥60. * For patients \> 16 years, Karnofsky score of ≥60. * No prior Hodgkin lymphoma directed therapy is allowed except for emergent mediastinal irradiation (\<1000cGy) for superior vena cava (SVC) syndrome. Exclusion Criteria: * Females who are pregnant (positive HCG) or lactating. * Karnofsky \<60% or Lansky \<60% if less than 16 years of age. * Age ≤1 year or \>29.99 years of age.