A Phase II Trila of Sunitinib Schedule 4/2 vs. Shedule 2/1 as First Line Therapy in Metastatic Renal Cell Carcinoma.

Inclusion Criteria: * Age≥18 years, ≤75 years, male or female * Advanced renal cell carcinoma is diagnosed histologically or pathologically * Treatment naive at diagnosed * At least one measurable tumor lesion (Response Evaluation Criteria In Solid Tumors) * Eastern Cooperative Oncology Group（ECOG) performance scale is 0 or 1 * The expected life span is ≥12 weeks * No contraindications for targeted therapy, with enough liver function and renal function and normal ECG recording Peripheral hemogram: neutrophil≥1.5×109/L, Plt≥100×109/L, Hgb≥90g/L Renal function: serum creatinine≤1.5 folds the upper limit of normal (ULN) For patients with non-metastatic liver dysfunction:alanine aminotransferase and aspartate aminotransferase≤2.5 ULN, For patients with metastatic liver dysfunction: alanine aminotransferase and aspartate aminotransferase≤5 ULN * The patients participate voluntarily and have signed the informed consent form Exclusion Criteria: * Patients who have received any systemic therapy including targeted therapy,immunotherapy,chemotherapy etc at diagnosed. * Pregnant and lactating women, or female patients of child-bearing age without taking contraceptive measures * Patients with severe acute infection without being controlled effectively or having pyogenic and chronic infections with persistently unhealed wounds * Past history of serious heart diseases, including: cardiac function classification ≥NYHA class II, unstable angina pectoris, myocardial infarction, arrhythmia requiring anti-arrhythmic drug therapy (excluding β-blockers or digoxin), and uncontrolled hypertension * Patients with a history of HIV infection or active phase of chronic hepatitis B/C * negative imaging examination result 4 weeks prior to enrollment) * Epilepsy patients requiring drug therapy (e.g. steroids or antiepileptic drugs) * A history of allogeneic organ transplantation