This study seeks to better characterize relationships between visual function and the progression (worsening) of geographic atrophy (GA) due to age-related macular degeneration (AMD). The study also will generate new information on the relationship between genetics and GA progression. This is a global, prospective, multicenter, epidemiologic study enrolling 200 participants with GA secondary to AMD. The study visits are scheduled to occur every 6 months. The anticipated duration of the study is up to 60 months.
Study Type
OBSERVATIONAL
Enrollment
202
No intervention administered in this study
Mean Change from Baseline in the GA Area as Assessed by Fundus Autofluorescence (FAF) up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Best Corrected Visual Acuity (BCVA) Score as Assessed by Early Treatment Diabetic Retinopathy Study (ETDRS) Chart up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in BCVA Score as Assessed by ETDRS Chart Under Low Luminance Conditions up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Binocular Reading Speed as Assessed by Minnesota Low-Vision Reading Test (MNRead) Cards or Radner Reading Cards up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Monocular Reading Speed as Assessed by MNRead Cards or Radner Reading Cards up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Binocular Critical Print Size as Assessed by MNRead Cards or Radner Reading Cards up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Monocular Critical Print Size as Assessed by MNRead Cards or Radner Reading Cards up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Near Activity Subscale as Assessed by National Eye Institute Visual Functioning Questionnaire 25-Item Version (NEI VFQ-25) up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Distance Activity Subscale as Assessed by NEI VFQ-25 up to Month 60
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Retina Specialty Institute
Pensacola, Florida, United States
Midwest Vision Research Foundation
Chesterfield, Missouri, United States
Char Eye Ear &Throat Assoc
Charlotte, North Carolina, United States
Retina Assoc of Cleveland Inc
Cleveland, Ohio, United States
Palmetto Retina Center
Florence, South Carolina, United States
Tennessee Retina PC.
Nashville, Tennessee, United States
Retina Res Institute of Texas
Abilene, Texas, United States
Texas Retina Associates
Dallas, Texas, United States
Retina Consultants of Houston
The Woodlands, Texas, United States
Strategic Clinical Research Group, LLC
Willow Park, Texas, United States
...and 53 more locations
Time frame: Baseline up to Month 60
Change from Baseline in Composite Scores as Assessed by NEI VFQ-25 up to Month 60
Time frame: Baseline up to Month 60
Change from Baseline in Functional Reading Independence Score up to Month 60
Time frame: Baseline up to Month 60
Percentage of Participants With Medical Events
Time frame: Baseline up to Month 60
Percentage of Participants With Ocular Events
Time frame: Baseline up to Month 60