Chemoradiotherapy With or Without Enteral Nutrition for Locally Advanced Thoracic Esophageal Carcinoma

Inclusion Criteria: * 18 to 75 years old * male or femalePathologically or cytologically proven esophageal squamous cell carcinoma * Clinical stage II or stage III * PG-SGA≧2 * Karnofsky performance score(KPS) ≧70 * Estimated life expectancy of at least 12 weeks * Hemoglobin≥90.0g/dL,white blood cell count（WBC）≥ 4000 cells/mm³,Platelet count≥100,000 cells/mm³ * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 2.5 times upper limit of normal,bilirubin normal * Creatinine normal OR creatinine clearance ≥ 60 mL/min * Patients have good compliance to treatment and follow-up of acceptance * Forced expiratory volume in one second（FEV1） ≥ 1.5 litre or ≥ 75% of the reference value * the functions of the heart, kidney, liver were basically normal, with no chemotherapy and radiotherapy contraindications Exclusion Criteria: * Patients with severely bowel function impaired or can not tolerate enteral nutrition * Patients with serious gastrointestinal obstruction, be unable to take food by mouth and can not / do not want to a feeding tube inserted * Patients have no risk of malnutrition * Patients have severe malnutrition (weight loss \>10% or \<30 g/L, BMI\<18.5 kg/m2 or hemoglobin\<90 g/L before the treatment * Patients who have severe vomiting, gastrointestinal bleeding, intestinal obstruction * Patients can not tolerate chemotherapy and radiotherapy * Patients who have distant metastasis * The primary tumor or lymph node already received surgical treatment (except for biopsy); * Patient who received radiotherapy for primary tumor or lymph node; * Patient who received chemotherapy or immunotherapy; * Patient who suffered from other malignant tumor; * Patient who have taken other drug test within 1 month; * Pregnant woman or Lactating Women and Women in productive age who refuse to take contraception in observation period; * Subject with a severe allergic history or idiosyncratic; * Subject with severe pulmonary and cardiopathic disease history; * Refuse or incapable to sign the informed consent form of participating this trial; * Drug abuse or alcohol addicted; * Subject with a Personality or psychiatric diseases, people with no legal capacity or people with limited capacity for civil conduct;