Acthar for Treatment of Post-transplant FSGS

Inclusion Criteria: * Age \> 18 years * Proteinuria \> 1 g/d by urine protein/creatinine ratio (UP/C) or 24 hour urine collection * If treated with an angiotensin-converting-enzyme inhibitor (ACEi) or Angiotensin II receptor blockers (ARB), must be on a stable dose for at least 2 weeks prior to enrollment * Newly diagnosed recurrent focal and segmental glomerulosclerosis (FSGS), or current/previous treatment of recurrent FSGS with no evidence of at least a partial response as defined by one or more of the following: 1. Recurrent FSGS confirmed by renal transplant biopsy (FSGS on light microscopy and/or foot process effacement on electron microscopy), with FSGS as the primary disease confirmed by native renal biopsy prior to transplant 2. FSGS confirmed by renal transplant biopsy (FSGS on light microscopy and/or foot process effacement on electron microscopy), within 18 months post transplant 3. Patients at any time period post transplant with an established diagnosis of recurrent FSGS in the first 18 months post transplant who did not respond to conventional therapy as defined by persistent proteinuria of \> 3 g/d by UP/C or 24 hour urine collection Exclusion Criteria: * Lactation, pregnancy or refusal of birth control in women of childbearing potential * Infection with human immunodeficiency virus (HIV), hepatitis B, hepatitis C, or parvovirus B-19 * Malignancy (with the exception of treated and cured basal cell or squamous cell carcinoma) * Evidence of diabetic nephropathy, transplant glomerulopathy or other pathologies that could be associated with secondary FSGS on renal transplant biopsy * Non-renal organ transplant (with the exception of pancreas transplant) * Contraindication to receiving Acthar®