Immune Modulation From Trichuris Trichiura

University of Aarhus1 enrolled

Overview

Mucosal immunology during helminth infection

The present study investigates the effects of Trichuris trichiura on human mucosal and systemic immunity in a single self-infected individual.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Crohn Disease Colitis, Ulcerative Intestinal Helminthiasis

Interventions

Trichuris trichiura eggsBIOLOGICAL

Live eggs from human whipworm, Trichuris trichiura

Eligibility

Sex: MALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The included volunteer is a researcher within parasitology with main focus on Trichuris trichiura and Trichiura suis. He planned to infect himself and contacted our department with the purpose of being monitored during this infection for safety (medical supervision) and research reasons. The only clinical criterion for his inclusion in the study was that he was healthy. Exclusion Criteria: * N/A

Outcomes

Primary Outcomes

Faecal egg excretion

Weekly monitoring of fecal egg counts by microscopy

Time frame: 30 weeks

Secondary Outcomes

Mucosal T cell associated cytokines

Biopsy sampling during established infection

Time frame: Week 15

Systemic immune parameters (eosinophilia, Subtypes of circulating T cells)

Weekly monitoring

Time frame: 30 weeks

Adverse events

The included individual was monitored clinically every week for the development of diarrhea and weight loss, and by blood samples for anemia and inflammatory parameters every other week.

Time frame: 30 weeks

Data from ClinicalTrials.gov

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