Effects of Lomitapide on Carotid and Aortic Atherosclerosis

Inclusion Criteria: • Adult patients (age ≥18 years) who are enrolled in LOWER Exclusion Criteria: * Patients with a prior history of carotid angioplasty, carotid stenting, or carotid atherectomy * Patients with a contraindication to MRI examination (i.e., brain aneurysm, implanted neural stimulator, implanted cardiac pacemaker, pacemaker wires or defibrillator, prosthetic heart valves, cochlear implant, ocular foreign body, or other implanted body) * Patients who have undergone a coronary stenting procedure in the preceding three weeks prior to enrollment * Patients prone to claustrophobia or known anxiety disorders that will interfere with the ability to acquire quality MRI scans * Patients with an implanted insulin pump * Patients with metal shrapnel or bullet wounds * Patients with a body mass index (BMI) \> 40 kg/m2 (since it may be difficult to position comfortably with the MRI scanner) * Patients who work with metal lathes (unless an orbit x-ray performed prior to the enrollment MRI scan has been done to rule out metal fragments in the eye)