Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications

Massachusetts General Hospital70,000 enrolled

Overview

Respiratory complications represent the second most frequent type of postoperative complications with an incidence estimated to range from 2.0% to 7.9% It has been shown that intra-operative protective ventilation is associated with a reduced risk of respiratory complications. The effects of intra-operative inspiratory oxygen fraction (FiO2) remain to be investigated. In this study, the investigators aim to investigate the association between intra-operative FiO2 and respiratory complication as well as surgical site infection and ICU admission in patients undergoing non-cardiothoracic surgery. The investigators primary hypothesis is that high intra-operative FiO2 increases the risk of postoperative respiratory complications independent of predefined risk factors.

Study Type

OBSERVATIONAL

Enrollment

70,000

Conditions

Respiratory Failure Acute Respiratory Failure Requiring Intubation Pulmonary Edema Pneumonia Surgical Wound Infection Mortality

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Non-cardiothoracic surgery at Massachusetts General Hospital between January 2007 and August 2015 * Tracheally intubated at the beginning of the procedure and extubated at the end of the procedure * above18 years of age Exclusion Criteria: * Missing information regarding main characteristics or the exposure variable