Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis Patients

Universitaire Ziekenhuizen KU Leuven166 enrolled

Overview

Does prolonged GnRH downregulation prior to ART improve the clinical pregnancy rate in postoperative endometriosis patients? (A single centre randomised controlled trial)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

166

Conditions

Endometriosis Infertility

Interventions

triptorelinDRUG

gonadotropin-releasing hormone (GnRH) agonist

ethinylestradiol + dienogestDRUG

oral oestroprogestogen

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 39 Years

Medical Language ↔ Plain English

Inclusion Criteria: * histologically proven endometriosis with complete treatment of all endometriosis lesions during laparoscopy * only first three ART cycles * normal uterine cavity * Eligible for ovarian stimulation with long agonist protocol Exclusion Criteria: * FSH\>20 IU/L * presence of large intramural fibroids (\> 3 cm) * \<4 oocytes obtained in any previous fresh ART cycle * ART with sperm derived from testicular biopsy * ART with Preimplantation Genetic Diagnosis/Screening

Locations (1)

UZ Leuven

Leuven, Belgium

Outcomes

Primary Outcomes

clinical pregnancy rate per initiated ART cycle

Time frame: participants will be followed for the duration of the ART cycle including the pregnancy test, an expected average of 10 weeks in the active comparator group and an expected average of 18 weeks in the experimental group

Data from ClinicalTrials.gov

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