Acute heart allograft rejection is a common complication after orthotopic heart transplantation. Primary objective of this study is to assess cardiac MRI as a tool for acute heart graft rejection screening, by detecting changes in myocardium structure especially extracellular volume.
Acute heart allograft rejection is a common complication after orthotopic heart transplantation. It can lead to multiple cardiac injuries and sometimes to patient's death. Currently, acute heart graft rejection screening is based on invasive strategies. Gold standard is represented by endomyocardial biopsies which provide side effects risk, rare but potentially fatal for the recipient. Cardiac MRI is an imaging tool recently used in cardiology. It is a non-invasive without any X-Ray exposition method well adapted to assess cardiac function and cardiac muscle composition. Cardiac MRI is probably a great tool to help the screening of acute heart allograft rejection, by detecting changes in myocardium structure. MRI validation as a screening tool for heart allograft rejection detection could help to reduce endomyocardial biopsies realised after orthotopic heart transplantation.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
SINGLE
Cardiac MRI is done using gadobenic acid intravenous injection 0.2 ml/kg one time
gadobenic acid intravenous injection 0.2 ml/kg is used one time for cardiac MRI assessment
Rouen University Hospital
Rouen, France
Number of patient with an acute rejection detected using Cardiac MRI after orthotopic heart transplantation
Time frame: Day 1
Extracellular volume as measured by Cardiac MRI
Time frame: Day 1
T1 as measured by Cardiac MRI
Time frame: Day 1
T2 as measured by Cardiac MRI
Time frame: Day 1
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