To assess whether albumin administration after an episode of hepatic encephalopathy (≥ grade II) improves survival at 90 days (mortality endpoint treated as a composite endpoint death and/ or liver transplantation).
To evaluate whether albumin administration after an episode of hepatic encephalopathy (≥ grade II) improves survival at 30, 90 and 180 days. * to evaluate the effects of albumin on hepatic encephalopathy recurrence during the study period. * To analyze whether albumin administration reduces hospitalization requirement. * To study the effects of albumin on circulatory dysfunction index (mean arterial pressure, renal function, plasma vasopressor hormones).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
128
1.5gr/Kg/day at least in the 24-48 hours after the hospitalization and 1.0 gr/Kg/day at 72 hours after the first dose.
Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, Spain
RECRUITINGCorporació Sanitària Parc Taulí
Sabadell, Barcelona, Spain
RECRUITINGHospital de Sant Joan Despí Moisès Broggi
Sant Joan Despí, Barcelona, Spain
Survival at 90 days. (The mortality endpoint is treated as a composite endpoint mortality and / or liver transplantation).
Time frame: 90 days
Survival at 180 days.
Time frame: 180 days
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Hospital Universitari Vall d'Hebron
Barcelona, Spain
RECRUITINGHospital Clínic de Barcelona
Barcelona, Spain
RECRUITINGHospital de la Santa Creu i Sant Pau
Barcelona, Spain
RECRUITINGHospital del Mar
Barcelona, Spain
RECRUITING