Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation

Yonsei University141 enrolled

Overview

Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively. Some of the recipients experience difficulty in weaning off from the mechanical ventilator due to various causes. This study is to investigate the relationship between the inflammatory gene polymorphism, known for acute lung injury, and the duration of mechanical ventilatory care for such liver transplantation recipients.

Study Type

OBSERVATIONAL

Enrollment

141

Conditions

Patients With Postoperative Mechanical Ventilation After Liver Transplantation

Interventions

Mechanical ventilatory lung careOTHER

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. 20-65 years old 2. scheduled for liver transplantation Exclusion Criteria: 1. Patients under mechanical ventilation prior to surgery 2. patients with muscular skeletal disorder, probable cause for respiratory depression 3. patients not able to read, or understand the consent form 4. ethnicity, other than asian 5. patients refusal

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

total duration of postoperative ventilator care

Time for successful weaning from ventilator could correlate with the inflammtory gene polymorphism, especially those related to acute lung injury.

Time frame: an expected average of 2-3 days

Data from ClinicalTrials.gov

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