Alcohol Diet and Drug Use Preceding Alcoholic Hepatitis

University Hospital Birmingham50 enrolled

Overview

ADDUP is an observational study of patients with alcoholic hepatitis. A structured interview is used to quantitatively estimate: 1. Alcohol use 2. Dietary intake 3. Drug use (legal and illegal) in the weeks preceding onset of acute alcoholic hepatitis. After interview patients are followed up for 12 months with regard to response to therapy and survival. The study is intended to explore potential precipitants of alcoholic hepatitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hepatitis, Alcoholic

Interventions

InterviewOTHER

Brief structured interview

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute alcoholic hepatitis * aged over 18 years * able to give informed consent Exclusion Criteria: * evidence of other acute or chronic liver disease * episode of alcoholic hepatitis in 6 months before admission * severe hepatic encephalopathy * delirium

Locations (1)

Queen Elizabeth Hospital Birmingham

Birmingham, West Midlands, United Kingdom

Outcomes

Primary Outcomes

Changes in alcohol intake, dietary intake or drug use before illness

Behavior before admission (Brief structured interview)

Time frame: 1 month

Secondary Outcomes

Survival after admission (Brief structured interview)

Survival

Time frame: 12 months

Response to treatment (Brief structured interview)

Response to treatment (corticosteroids, pentoxifylline or supportive medical care) after 1 week, measured by Lille score

Time frame: 1 week

Data from ClinicalTrials.gov

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