Multiple Ascending Dose Study in Healthy Volunteers

Inclusion Criteria: * Healthy adult males and females between 18 and 50 years of age. * Body weight ≥ 50 kg and BMI within the range of 18 to 30 kg/m2 Exclusion Criteria: * Medical, psychiatric illness or history of depression that could, in the investigator's opinion, compromise the subject's safety * Significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. * History of clinically significant central nervous system (eg, seizures), cardiac, pulmonary, metabolic, renal, hepatic, or gastrointestinal (GI) conditions. * PR interval ≥ 220 msec or QRS duration ≥ 120 msec or QTcB / QTcF interval \> 450 msec obtained at screening visit or prior to the first dose of study drug. * Liver function tests greater than the upper limit of normal. * Positive blood screen for human immunodeficiency virus (HIV antibody), hepatitis B virus surface antigen, or hepatitis C virus antibody at screening. * Urinalysis positive for protein or glucose. * A positive screen for alcohol, drugs of abuse, or tobacco use. * Inability to comply with food and beverage restrictions during study participation. * Donation or blood collection or acute loss of blood prior to screening.