Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.
After approval of the regional ethics committee, patients (n=16) undergoing combined cardiac surgery procedures during normothermic CPB will be included after informed consent. Systemic and renal variables will be measured by pulmonary artery and renal vein catheters. Glomerular filtration rate (GFR) will be measured by renal extraction of 51Cr-EDTA and renal blood flow (RBF) by the infusion clearance technique for para-aminohippuric acid (PAH) corrected for by renal extraction of PAH. Repeated measures ANOVA followed by Fisher's PLSD post-hoc test were used for statistical analyses
Study Type
OBSERVATIONAL
Enrollment
28
During cardiac surgery, the subjects are routinely undergoing cardiopulmonary bypass
Department of thoracic anesthesia, Sahlgrenska University Hospital
Gothenburg, Sweden
Renal Blood Flow (RBF)
Renal blood flow measured with PAH clearance
Time frame: 6 hours
Glomerular Filtration Rate (GFR)
GFR measured by renal extraction of 51Cr-EDTA
Time frame: 6 hours
Renal Oxygenation
Renal oxygen extraction, defined as renal oxygen consumption divided by renal oxygen delivery
Time frame: 6 hours
Excretion of NAG
Urinary biomarker of tubular renal injury
Time frame: 24 hours
Development of Acute Kidney Injury (AKI)
AKI according to AKIN criteria
Time frame: 72 hours
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