Phase II Evaluation of AHCC for the Eradication of HPV Infections

The University of Texas Health Science Center, Houston50 enrolled

Overview

This is a phase II randomized, double-blind placebo-controlled, crossover trial. The primary outcome of this trial is achieving durable eradication persistent high risk HPV infection determined by HPV negative test results achieved while on active treatment with AHCC and maintained for 6 month post supplementation and 12 months post completion of AHCC treatment compared to placebo.

This is a phase II randomized, double-blind placebo-controlled, crossover trial. The primary outcome of this trial is achieving durable eradication HPV infection determined by HPV negative test results achieved while on active treatment with AHCC and maintained for 6 month post supplementation and 12 months post completion of AHCC treatment for Group 1. We will follow all patients for at least 12 months and up to 30 months depending on success of achieving a negative HPV testing results. After receiving AHCC 3 grams x 6 months if positive at the end of 12 months of study treatment, they are considered a treatment failure. If negative after completion of 6 months of AHCC supplementation + 6 months of placebo, they will continue on study for another six months (2 visits) to confirm they remain HPV negative and durable response. Group 2 will serve as untreated control for all time points (end of supplementation, then 6, 9, and 12 months post end of AHCC supplementation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Human Papilloma Virus Dysplasia CIN1 CIN2

Interventions

AHCC 3 grams once a dayDIETARY_SUPPLEMENT

AHCC supplementation x 6 months with Placebo x 6 months

PlaceboOTHER

Placebo supplementation x 12 months

Eligibility

Sex: FEMALEMin age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * • Women over 30 years of age who have a HPV positive test and normal/negative cytology, atypical cells, ASCUS, or CIN1 or CIN2 cervical dysplasia within three months of study entry. * Women must have had 2 other HPV positive tests with normal/negative cytology, atypical cells, ASCUS, or CIN1 or CIN2 cervical dysplasia * 1 greater than 6 months and no more than 18 months prior to study entry * 1 greater than 24 months prior to study entry. * Women of child bearing potential must have a negative urine pregnancy test within 7 days of therapy start. * Patients must have adequate hematologic, renal, and hepatic function as noted from labs within the previous 12 months: ANC \>/= 1,500 cells/mm3, platelets 100,000 \>/= cells/mm3; Creatinine clearance\>/= 60 mL/min (estimated by Cockcroft Gault equation), total bilirubin, SGPT, SGOT, and alkaline phosphatase \</= 1.5 times normal. * Patients of child-bearing age must agree to use effective methods of contraception (oral contraceptives, condoms, etc.) while on study. Exclusion Criteria: * • History of myocardial infarction within past 6 months, unstable angina, CHF, or uncontrolled hypertension (\> 140/90). * Women with a current or prior diagnosis of cancer * Women with a current diagnosis of CIN3 cervical dysplasia * Women that are pregnant or breast feeding. * Women with a history of Hepatitis (autoimmune, A, B, or C) or antigen positive * Patients with history of significant psychiatric disorders (schizophrenia, bipolar, psychosis) or uncontrolled seizures. * Patients with significant medical co-morbidities at the discretion of the primary Gynecologist. Including immunosuppressive conditions (i.e. HIV+, rheumatoid arthritis, etc) or taking immune modulation mediations (i.e. immunosuppressants) * Women that have taken AHCC within the past six months. * Women currently taking other immune modulating nutritional supplements. * Patients who have undergone a hysterectomy (supracervical hysterectomy allowed)

Locations (1)

UTHealth Medical School at Houston

Houston, Texas, United States

Outcomes

Primary Outcomes

Roche, COBAS HPV DNA Assay (Pleasanton, CA)

HPV DNA testing

Time frame: once every 3 months for 12 months up to 18 months

Secondary Outcomes

Interferon beta

Evaluation of Interferon Beta level

Time frame: once every 3 months for 12 months up to 18 months

Interferon gamma

Evaluation of Interferon gamma level

Time frame: once every 3 months for 12 months up to 18 months

NK Cells

Evaluation of Natural Killer (NK) cells

Time frame: once every 3 months for 12 months up to 18 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.