CPAP for Infantile Pompe Disease

National Taiwan University Hospital3 enrolled

Overview

Patients with infantile onset Pompe disease will be trained with continuous positive airway pressure to see if hypernasality can be improved.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Pompe Disease

Interventions

continuous positive airway pressurePROCEDURE

CPAP training for muscle strength

Eligibility

Sex: ALLMin age: 4 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. confirm as Pompe disease 2. Age 4 and can speak 2-words sentence by order 3. mild to severe hypernasality 4. have regular speech therapy for 8 weeks or longer Exclusion Criteria: (1）hearing loss （2）congenital pharyngeal or laryngeal structure anomalies including cleft palate （3）cerebral palsy （4）recent otitis media effusion （5）very severe hypernasality （6）use non-invasive ventilator

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan, Taiwan

RECRUITING

Outcomes

Primary Outcomes

decrease in hypernasality

score hypernasality degree and compare

Time frame: 6 months

Secondary Outcomes

increase in speech intelligibility

score speech intelligibility degree and compare

Time frame: 6 months

Central Contacts

Yin-Hsiu Chien

CONTACT

886223123456 chienyh@ntu.edu.tw

Data from ClinicalTrials.gov

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