The human fetus swallows over 200 ml of amniotic fluid per kilogram of weight each day and such swallowing is essential for normal small bowel development.Growth factors found in the amniotic fluid have been shown to promote proliferation of fetal intestinal cells. As feeding intolerance is a common problem among premature neonates, the investigators will study the role of enteral administration of simulated amniotic fluid solution in prevention of feeding intolerance and NEC in premature neonates.
Very Low Birth Weight (VLBW) neonates. Participants will be followed for the duration of hospital stay until discharge or death.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
40
simulated amniotic fluid 20cc/kg/day enterally for a maximum of 7 days.
distilled water 20 ml/kg/day for maximum of 7 days.
Ain Shams University
Cairo, Cairo Governorate, Egypt
RECRUITINGNecrotizing enterocolitis by modified Bell criteria, mortality in percentage, hospital stay in days. The outcome measure will be assessed within 2 months
Time frame: participants will be followed for the duration of hospital stay, an expected average of 4 weeks
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