Pomalidomide in Relapsed and Refractory Multiple Myeloma (RRMM)

Inclusion Criteria: * Diagnosed with symptomatic multiple myeloma (according to International Myeloma Working Group (IMWG) 2009 criteria) and have measurable disease * Participants must require therapy for relapsed and/or refractory disease * Participants must have received ≥ 2 treatment lines of anti-myeloma therapy (induction therapy followed by autologous stem-cell transplantation (ASCT) and consolidation/maintenance will be considered as one line). * Participants must have received prior treatment with both lenalidomide and proteasome inhibitor, either as single agents or in combination regimens * All participants must have failed treatment with either lenalidomide and proteasome inhibitor in one of the following ways: 1. Documented progressive disease on or within 60 days of completing treatment with lenalidomide and/or proteasome inhibitor ; or 2. In case of prior response \[≥ partial response (PR)\] to lenalidomide or proteasome inhibitor, participants must have relapsed within 6 months after stopping treatment with lenalidomide and/or proteasome inhibitor containing regimens; or 3. Participants who have not had a ≥ minimal response (MR) despite receiving at least 4 cycles of treatment or who have developed intolerance/toxicity after a minimum of two cycles of lenalidomide and/or proteasome inhibitor containing regimen * Patients must have received adequate prior alkylator therapy in one of the following ways 1. As part of a stem cell transplant; or 2. A minimum of 4 consecutive cycles of an alkylator based therapy; or 3. Progression on treatment with an alkylator; provided that the participant received at least 2 cycles of an alkylator containing therapy. * Life expectancy of at least 3 months * Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2 * Required laboratory values within 14 days of treatment: * Absolute neutrophil count ≥ 1.0 x109 /L (growth factor support is permitted) * Platelet count ≥ 30 x 109/L (platelet transfusion is permitted) * Creatinine clearance \> 30 mL/min * Corrected serum calcium ≤ 3.5 mmol/L * Haemoglobin ≥ 8 g/dL (blood transfusion support is permitted) * Aspartate aminotransferase (AST) or Alanine aminotransferase (ALT) \< 3 times Upper Limit of Normal (ULN) * Serum total bilirubin \< 17 µmol/l * Participants must consent to provide the bone marrow samples specified at screening and throughout the trial, in order to enter the trial. Confirmation of receipt of the sample from the lab must be received before treatment commences.. * Able to give informed consent and willing to follow trial protocol * Aged over 18 or over * Females of childbearing potential (FCBP) must agree to utilise one reliable form of contraception for 28 days prior to starting trial treatment, during the trial, and for 28 days after trial treatment discontinuation and even in the case of dose interruption and must agree to regular pregnancy testing during this timeframe * Females must agree to abstain from breastfeeding during trial participation and 28 days after trial drug discontinuation * Males must agree to use a latex condom during any sexual contact with FCBP during the trial, including during any dose interruptions and for 28 days following discontinuation from this trial even if he has undergone a successful vasectomy * Males must also agree to refrain from donating semen or sperm while on pomalidomide, including during any dose interruptions and for 28 days after discontinuation from this trial * All participants must agree to refrain from donation blood while on trial drug, including during dose interruptions and for 28 days after discontinuation from this trial Exclusion Criteria: * Previous therapy with pomalidomide * Hypersensitivity to thalidomide, lenalidomide, cyclophosphamide or dexamethasone * Participants with non-secretory multiple myeloma * Peripheral neuropathy ≥ Grade 3 * Participants who have received an allogeneic bone marrow or allogeneic peripheral blood stem cell transplant * Participants who are planned for a stem cell transplant post MUK Seven trial treatment * Antitumour therapies including investigational medicinal products at any dose within 28 days before the start of protocol treatment (or 5 half-lives, whichever is longer). Bisphosphonates for bone disease and radiotherapy for palliative intent are permitted. * Participants with any of the following 1. Uncontrolled congestive heart failure 2. Myocardial infarction within 12 months prior to starting trial treatment 3. Unstable or poorly controlled angina pectoris, including Prinzmetal variant angina pectoris. * Participants with gastrointestinal disease that may significantly alter absorption of pomalidomide * Participants with a history of other malignancies within 5 years before the date of study entry (exceptions are squamous and basal cell carcinomas of the skin, carcinoma in situ of the cervix or breast, or other non-invasive lesion that is considered cured with minimal risk of recurrence within 5 years). * Participants unable or unwilling to undergo antithrombotic prophylactic treatment * Pregnant or breastfeeding females * Participants known to be seropositive for HIV, or active infectious hepatitis A, B or C * Any condition including the presence of laboratory abnormalities, which places the participant at unacceptable risk if he/she were to participate in the trial