Myocardial fibrosis is the fundamental substrate for the development of heart failure. Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and T1 mapping. Patients: Prospective longitudinal observational multicenter study of consecutive patients with suspected or known non-ischemic cardiomyopathy. Imaging: Non-invasive measures of myocardial fibrosis: native T1, extracellular volume fraction (ECV) and LGE. Primary endpoints: all cause and cardiovascular mortality. Secondary endpoints: arrhythmic composite and HF composite endpoints.
Study Type
OBSERVATIONAL
Enrollment
1,629
Vincent's University
Sydney, New South Wales, Australia
German Heart Institute Berlin
Berlin, Germany
Guy's and St. Thomas' Hospital Trust
London, United Kingdom
King's College Hospital
London, United Kingdom
Survival
number of deaths
Time frame: 1 year
Rate of Arrhythmia
number of fatal or aborted sudden cardiac death events (including a documented appropriate shock from ICD)
Time frame: 1 year
Rate of HF events
Number of HF death and unplanned HF hospitalization
Time frame: 1 year
Rate of deaths due to cardiovascular causes
Number of composite of sudden cardiac death (SCD), death from HF, death from stroke or thromboembolic event
Time frame: 1 year
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