Assessment of the Force Frequency Relationship of the Myocardium After On-pump CABG Surgery

University of Liege20 enrolled

Overview

The aim of the study is to determine whether increasing the heart rate by epicardial atrial pacing after surgery improves the contractile force of the myocardium. After complete weaning from CPB, several pressure-loops of the LV will be recorded at different levels of preload using transoesophageal echo, invasive blood pressure monitoring. The preload will be manipulated by adding fluid from the CPB reservoir or draining fluid into the CPB reservoir.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Adult Cardiac Surgery

Interventions

External Pacing BoxDEVICE

Atrial pacing using an external pacing box

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CABG only surgery * Preopeartive LVEF ≥ 53 % * Use of epicardial pacing wires to assist CPB weaning Exclusion Criteria: * Contra-indication to TEE * AV block at the time of CPB weaning * Sinus rhythm less than 50 or more than 90 BPM after CPB weaning.

Outcomes

Primary Outcomes

End-systolic elastane of the left ventricle.

Time frame: 30 minutes after CPB weaning

Data from ClinicalTrials.gov

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