EFFects of Thrombophilia on the Outcomes of Assisted Reproduction Technologies

G. d'Annunzio University687 enrolled

Overview

Both hereditary and acquired thrombophilia have been associated with recurrent miscarriage and pregnancy complications. Thrombophilia could favor the development of thrombosis of the maternal vasculature and obstacle placentation. Some studies have suggested a role of thrombophilia in the failure of assisted reproductive techniques although this association has been recently questioned. The scope of this study is to evaluate the effect of thrombophilia on the implantation rate and live birth rate in women undergoing ART. Design: prospective, observational study Primary end-point: live birth rate. Secondary end-points: implantation rate, venous thromboembolic events during ART up to 6 weeks post-partum

Study Type

OBSERVATIONAL

Enrollment

687

Conditions

Birth Rate Embryo Implantation Reproductive Techniques Thrombophilia

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * women undergoing ART * age 18 years or older Exclusion Criteria: * ongoing anticoagulant therapy * previous venous thromboembolism * no informed consent

Outcomes

Primary Outcomes

Live birth rate

Time frame: Participants will be followed for the duration of the pregnancy, an expected average of 9 months

Secondary Outcomes

implantation rate

Time frame: Participants will be followed from the implantation to the ultrasonography to document the gestational sac, an expected average of 7 weeks