The purpose of this research study is to determine what causes pain after surgery to increase or decrease over time.
Before surgery, study participants will be asked questions about age, gender, race/ethnicity, annual income, and education level. Study participants will also be questioned regarding prior pain experiences, their mood and how they think about pain. A small test tube of blood, a cheek swab or a saliva sample will be taken to see what genetic differences may influence individuals pain after surgery. After surgery, study participants will be asked questions about their pain intensity while in the hospital. Additional information will be collected about the effects of pain medicine, and their recovery from surgery. Following discharge from the hospital, study participants will be contacted monthly to confirm continued communication. Study participants will also be contacted six months after surgery, and asked to complete a final survey about their pain after surgery.
Study Type
OBSERVATIONAL
Enrollment
428
Study the dynamic nature of pain
Research variants in genes related to pain sensitivity, analgesic sensitivity and opioid response
UF Health
Gainesville, Florida, United States
Measure postoperative pain scores change with respect to time
Pain scores will be measured using previously established pain scale and Questionnaire
Time frame: up to 7 days
Measure variables that contribute to postoperative pain scores
Variables: clinical, biological, psychological, and social factors
Time frame: up to 6 months
Measure timing patterns that may influence development of persistent postsurgical pain (PPP)
Different patterns of pain analgesia-pain cycles
Time frame: up to 6 months
Genetic testing
Specific single nucleotide polymorphisms
Time frame: up to 1 day
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