The overarching goal of this study is to characterize the effects of cannabinoids on working and episodic memory.
This study will be achieved by studying the acute effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis and a cannabinoid-1 receptor (CB1R) agonist, on a wide range of memory tasks in healthy human subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
80
VA Connecticut Healthcare System
West Haven, Connecticut, United States
Rey Auditory Verbal Learning Test (RAVLT)
a measure of verbal episodic memory
Time frame: +35 minutes after infusion
N-Back Task
a measure of working memory
Time frame: +65 minutes after infusion
Clinician Administered Dissociative Symptoms Scale (Total Score)
Time frame: Baseline, +10, +85, and +240 minutes after the first infusion
Visual Analog Scale (Total Score)
a measure of THC intoxication
Time frame: Baseline, +10, +85, +240 minutes after the first infusion
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