Miromatrix Biological Mesh for Ventral Hernia Repair

Inclusion Criteria: * between 18 and 80 years old on the day of study enrollment * ventral or incisional hernia greater than 9 cm2 for which the physician anticipates ability to achieve midline fascia closure following a retro-rectus repair/component separation * hernia classified as CDC class 1 or 2 preoperatively * able and willing to sign the consent form and comply with all study visits and procedures * commit to non-smoking for at least 4 weeks prior to procedure Exclusion Criteria: * sensitivity to porcine material * scheduled for a concomitant procedure of a wound classified as other than clean * immunocompromised or at risk of immunosuppression (i.e. be HIV positive, be experiencing organ rejection, be a recent or anticipated chemotherapy recipient) as determined by the Investigator * BMI ≥40 * A1C level ≥10.0 * participating in another clinical study * cirrhosis, and/or ascites * diagnosed with a collagen vascular disorder * American Society of Anesthesiology (ASA) Class 4 or 5 * allergic to tetracycline or kanacmycin * life expectancy of less than 2 years at the time of enrollment * any condition in the opinion of the Investigator that would preclude the use of the study device, or preclude the subject from completing the follow-up requirements