Utility of Prolonged-release Pirfenidone in the Progression of Chronic Kidney Disease

Inclusion Criteria: 1. Patients between 10 and 40 years old with CKD 2. Diagnosis of CKD stage 1 to 4 according with KDIGO definition and classification 3. No glucocorticoids, cyclophasphamide, mycophenolate, or other immunosuppressive drugs for at least two months before starting PFD administration 4. Sign of consent forms Exclusion Criteria: 1. Known intolerance to PFD 2. CKD stage V according with KDOQI classification 3. Post-transplant patients 4. History of peptic ulcer within six months 5. History of cerebrovascular disease within six months 6. Evidence of hepatic disease 7. Pregnancy or breast feeding 8. Malignancy