Many studies have demonstrated that endometrial scratch significantly increase pregnancy rate in patients undergoing in vitro fertilization and embryo transfer. However, only a limited number of studies have been conducted in frozen thawed transfer (FET) cycle. Nowadays, in FET cycles, endometrial scratch is mainly performed on two different time points: 1) luteal phase in the previous cycle; 2)early follicular phase in the current cycle. However, few studies have compared the effectiveness of those two different endometrial scratch methods performed in different timing. The aim of this study is to find the best timing of endometrial scratch in FET cycles.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
400
local injury to the endometrium by Pipelle
Reproductive Medical Center, 1st Affiliated hospital of Zhengzhou University
Zhengzhou, Henan, China
RECRUITINGClinical pregnancy rate
See heart beat with ultrasonic exam.
Time frame: 35 days after embryo transfer
Ectopic pregnancy rate
No sac can be seen inside uterine 35 days after embryo transfer, but with high hCG level
Time frame: 35 days after embryo transfer
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