Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

Early Phase 1CompletedNCT02410980

University of California, Irvine15 enrolled

Overview

The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.

The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques. 1. Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany) 2. Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Collagen Fibril Alteration

Interventions

Tretinoin cream 0.1%DRUG

Assessment of the skin change

Eligibility

Sex: FEMALEMin age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female 45 years of age or older - Skin type scale I to III Exclusion Criteria: * Large amount of dark, coarse hair on the arms * History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex * Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study. * History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma. * History of diabetes * Currently pregnant or nursing

Locations (1)

Beckman Laser Institute Medical Clinic

Irvine, California, United States

Outcomes

Primary Outcomes

Skin Collagen/Elastin ratio over time - Change from baseline in sun exposed, and non sun exposed skin areas.

The effects of tretinoin cream on human skin will be measured.

Time frame: up to 2 months

Data from ClinicalTrials.gov

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