Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism

Vanderbilt University Medical Center39 enrolled

Overview

Pseudohypoparathyroidism type 1a (PHP1a) is a rare disease that causes childhood obesity and learning difficulties. This study will investigate eating behaviors and perform cognitive testing on children with PHP1a. The investigators will compare their results to those of healthy siblings and other obese children.

Pseudohypoparathyroidism type 1a (PHP1a) is a genetic disorder that causes early-onset, syndromic obesity and cognitive impairment. This study aims to evaluate eating behaviors, cognition and executive function in children with PHP1a, compared with healthy siblings and matched obese controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pseudohypoparathyroidism Albright Hereditary Osteodystrophy

Eligibility

Sex: ALLMin age: 6 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of PHP1a, sibling of a patient with PHP1a or matched obese control Exclusion Criteria (PHP1a): * Treatment with appetite-altering drug or initiation of a new weight loss program in the past 3 months * Type 2 diabetes Exclusion Criteria (Controls): * Obesity due to a genetic syndrome, growth hormone deficiency, untreated hypothyroidism, Cushing syndrome or exogenous glucocorticoid administration * Weight loss greater than 10% over the previous 6 months * Autism or other significant learning disorder * Type 2 diabetes * Other significant medical condition

Locations (1)

Vanderbilt University

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Intelligence Quotient

Intelligence quotient as measured by Kaufman Brief Intelligence Test, 2nd Edition. This scale yields standard scores where the mean is 100 and one standard deviation is 15. Higher scores indicate better function.

Time frame: one day

Data from ClinicalTrials.gov

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