Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral Brexpiprazole (OPC- 34712) in Adolescents With Schizophrenia

Inclusion Criteria: * Male and female subjects 13 to 17 years of age, inclusive, at the time of informed consent. * Subjects with a current diagnosis of primary schizophrenia spectrum or bipolar spectrum disorder, as defined by DSM-IV-TR criteria, and confirmed by K-SADS-PL. * No psychiatric hospitalizations within the past 12 weeks. * Subjects require treatment with antipsychotic medications. * Subjects who have received previous outpatient antipsychotic treatment at an adequate dose for an adequate duration (at least 6 weeks) and who showed a previous good response to such antipsychotic treatment (other than clozapine) in the last 12 months. * Subjects with a body weight at Screening greater than or equal to 30 kg. Exclusion Criteria: * Sexually active females of childbearing potential and male subjects who are not practicing two different methods of birth control with their partner (or abstinence) during the trial and for 30 days after the last dose of trial medication * Females who are breast-feeding and/or who have a positive pregnancy test result prior to receiving trial drug. * Subjects who have received continuous medication therapy to treat schizophrenia and schizophrenia spectrum diagnosis for less than six months prior to first dose of study medication AND subjects who have received continuous medication therapy to treat bipolar and bipolar spectrum disorder for less than two months in the past three years; or subjects who require more than one antipsychotic.. * Subjects with a current DSM-IV-TR diagnosis other than schizophrenia spectrum , bipolar spectrum, including any Axis I or Axis II (DSM-IV-TR) disorder. * Subjects with a clinical presentation and/or history of any neurodevelopmental disorder * Subjects who have met DSM-IV-TR criteria for substance abuse or dependence within the past 180 days. * Subjects who currently have clinically significant neurological, hepatic, renal, metabolic, hematological, immunological, cardiovascular, pulmonary, or gastrointestinal disorders such as any history of myocardial infarction, congestive heart failure, HIV seropositive status/acquired immunodeficiency syndrome, or chronic hepatitis B or C. * Subjects with IDDM (ie, any subjects using insulin) are excluded. Subjects with non-IDDM may be eligible for the trial if their condition is stable. * Subjects with epilepsy or a history of seizures. * Any major surgery or blood transfusion within 30 days prior to first dose of trial medication. * Subjects with a positive drug screen for cocaine or other illicit drugs, or alcohol are excluded and may not be retested or re-screened. * Prohibited concomitant medications used within the exclusionary period prior to Day 1 of the Dose Escalation Phase or anticipated need for such medications during the trial. * Subjects who participated in a clinical trial and were exposed to IMP within the last 30 days or who participated in more than two interventional clinical trials within the past year. * Subjects with a history of true allergic response (ie, not intolerance) to more than one class of medications. * Inability to tolerate oral medication or swallow tablets.