Multiple Ascending Dose Study in Healthy Male Subjects and Overweight to Obese Male and Female Type 2 Diabetes Mellitus (T2DM) Patients

Inclusion criteria: Healthy subjects: * Males, between 18 and 55 years of age, inclusive. * Body mass index (BMI) between 20.0 and 30.0 kg/m\^2, inclusive; body weight between 50.0 and 120.0 kg, inclusive. * Certified as healthy by comprehensive clinical assessment (detailed medical history, complete physical examination). Comorbidities of higher weight (eg, mild impaired glucose tolerance, mild hypertension, mild hyperlipidemia) are permitted unless, per investigator, these conditions hamper participation. * Normal vital signs after 10 minutes resting supine: * 95 mmHg \<systolic blood pressure (SBP) \<150 mmHg. * 45 mmHg \<diastolic blood pressure (DBP) \<100 mmHg. * 50 bpm \<heart rate (HR) \<100 bpm. * Standard 12-lead electrocardiogram (ECG) parameters after 10 minutes resting in supine position within; 120 ms \<PR \<220 ms, QRS \<120 ms, QTc ≤430 ms, normal ECG. * Normal 24-hour Holter electrocardiography at screening. * Laboratory parameters within normal range; however serum creatinine, alkaline phosphatase, hepatic enzymes (aspartate aminotransferase, alanine aminotransferase), and total bilirubin (unless subject has Gilbert syndrome) should not exceed upper laboratory norm (ULN). T2DM patients: * Males and females, 18-70 years of age. * Body weight 50.0-150.0 kg, BMI 28.0 - 42.0 kg/m\^2. * Diagnosis of T2DM for at least 1 year with stable metformin prior to inclusion; comorbidities related to T2DM but otherwise healthy. * Normal vital signs supine: * 95 mmHg \< SBP \<160 mmHg * 45 mmHg \< DBP \<100 mmHg * 50 bpm \< HR \<100 bpm * Normal standard 12-lead ECG in supine position unless abnormality is clinically irrelevant. * Laboratory parameters in normal range unless abnormality is clinically irrelevant or strongly associated with T2DM; total bilirubin not to exceed ULN. * Fasting plasma glucose ≥90 mg/dL. * HbA1c ≥6.5% and ≤8.5%. * Females: Sterilization at least 3 months before inclusion or postmenopausal. Both: * Signed written informed consent. * Not supervised/confined for legal or administrative reasons. * Male subject with partner of childbearing potential (including lactating women) must use double contraception method. * Male subject with pregnant partner must use a condom up to 2 months after last dosing. * Male subject agreed not to donate sperm up to 2 months after last dosing. * Not undergoing physical training program/planning changes in activity; not vegetarian or following special diet. Exclusion criteria: Healthy subjects: * History of clinically relevant disease/signs of acute illness. * History of drug hypersensitivity/allergic disease. * Smoking more than 5 cigarettes/day. * Any medication within 14 days before inclusion or within 5 times elimination/pharmacodynamic half-life of the medication and during study; vaccination within last 28 days, biologics given within 4 months before inclusion. T2DM patients: * History/presence of clinically relevant disease/signs of acute illness not related to patient's metabolic status. * History/presence of drug hypersensitivity or allergic disease. * Smoking more than 5 cigarettes per day. * If female, pregnancy/breast-feeding. * Any intake of medication during treatment period and within 21 days before first dosing or within 5 times half-life of the medication, except: metformin, standard antihypertensive treatment, statins, acetyl salicylic acid. * Thyroid hormone replacement is allowed if dose was stable for 3 months prior to screening. * Individual background therapy, considered necessary for the patient's welfare, that could not be discontinued for the duration of the study, may be given at the discretion of the Investigator, with a stable dose (when possible) and only if its intake is unlikely to interfere with the investigational product. * Treated with sulphonyl-ureas up to 3 months, proton pump inhibitors up to 1 week prior to dosing. * Vaccination within last 28 days, any biologics within 4 months before inclusion. * Severe hypoglycemia resulting in seizure/unconsciousness/coma/hospitalization for diabetic ketoacidosis in last 3 months before screening. * Persistent hyperglycemia not controlled by metformin/diet/exercise. * Diabetic neuropathy, retinopathy, nephropathy or renal impairment. * Hepatic impairment. * Unstable hypo- or hyperthyroidism. Both: * Headaches/migraine. * Recurrent nausea/vomiting. * Blood donation within 1 month before inclusion. * Symptomatic postural hypotension, irrespective of decrease in BP, or asymptomatic postural hypotension defined as decrease in SBP ≥20 mmHg within 3 minutes when changing from supine to standing. * History/presence of drug or alcohol abuse. * Positive result: hepatitis B surface antigen, anti-hepatitis C virus antibodies, anti-human immunodeficiency virus 1 and 2 antibodies. * Any condition affecting gastric emptying or absorption from GI tract. * Surgically treated obesity, bariatric surgery. * Severe dyslipidemia with fasting triglycerides \>450 mg/dL. * History of pancreatitis or pancreatectomy. * Amylase/lipase \>3 ULN. * History of thyroid cancer or a genetic condition that predisposes to thyroid cancer. * Elevated basal calcitonin. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.